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An activity-dependent decrease in the hyperpolarizing Cl gradient decreases GABAergic inhibition and unmasks an outward flux of HCO 3 ions through GABA A Rs, resulting in neuronal depolarization/excitation (Bormann et al., 1987

Some public health agencies, such as Public Health England (now the Office for Health Improvement and Disparities), have endorsed e-cigarettes as substantially less harmful than traditional cigarettes, while simultaneously calling for regulation to limit unintended use among people who never smoked [9]